Solubility Criteria for Veterinary Drugs

This Stimuli article is the first step toward the development of a general chapter addressing solubility criteria for veterinary drug products. The current criteria for classifying drug solubility are based on human gastrointestinal (GI) physiology. These criteria may not be appropriate to the unique conditions encountered within the GI tract of veterinary species. Thus, this article discusses the relationship between the species-specific GI characteristics and the criteria appropriate for describing drug solubility in veterinary species. Initially the discussion focuses on dogs and cattle, the most common veterinary patients in smalland food-animal practices, respectively. Later the discussion will include various other veterinary species of interest. dx.doi.org/10.14227/DT240117P22 e-mail: [email protected]. *Correspondence should be addressed to: Margareth R. C. Marques, Ph.D., Senior Scientific Liaison, USP, 12601 Twinbrook Parkway, Rockville, MD 20852-1790; tel 301 816 8106, e-mail: [email protected]. Disclaimer: This document represents a consensus of the personal views of the authors and does not necessarily represent the views of the authors' respective companies or organizations, nor does it represent the policies or guidelines of those companies or organizations.